Advanced Sequencing Precision
MGI's DNBSEQ™ technology uses DNA Nanoballs (DNBs) for highly accurate and efficient sequencing. DNA is circularized and converted into DNBs, which are loaded onto patterned array chips. Sequencing begins with the addition of a primer, followed by the introduction of fluorescently labelled dNTP probes and DNA polymerase. The system captures images of the DNBs, which are then processed by MGI’s proprietary software to determine the DNA sequence.
Key features include:
• DNA Circularization & DNB Preparation
• Patterned Arrays for high density
• Combinatorial Probe Anchor Synthesis (cPAS)
• Pair-End Sequencing for greater depth
• Advanced Fluidics & Imaging Systems
DNBSEQ™ offers improved sequencing accuracy, reduced duplication rates, and higher SNP and indel detection. Combined with PCR-free library construction, it provides superior performance.
How does DNBSEQTM sequencing technology work?
DNBSEQTM, a cutting-edge sequencing technology developed by MGl and built around DNA nanoballs (DNBs), enables highly accurate and efficient DNA sequencing.
Applications
The DNBSEQ sequencing platform is engineered for high throughput, delivering exceptional data accuracy with low duplication rates and minimal index hopping. This makes it a highly cost-effective solution for large-scale genomic initiatives and population-level studies.
It is ideally suited for:
Large-Scale Genomics: Powering massive human genome cohort projects, as well as animal and plant population sequencing for molecular breeding.
Clinical Applications: Enabling precision oncology, liquid biopsies, and the identification of pathogenic genes in rare diseases.
Advanced Research: Supporting diverse applications such as pathogen metagenomics surveillance, single-cell sequencing, and multi-omics analysis.
In essence, the DNBSEQ platform is built to meet the demanding, high-throughput needs of both research and clinical environments.
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