Vega delivers 60 Gb of long reads per run of the best-in-class accurate HiFi reads and complete genomic, transcriptomic, and epigenetic data for individual labs.
No batching and no waiting. Manage project times more effectively by sequencing in-house and control your timelines from start to finish.
Adopting HiFi reads is now simpler than ever with the PacBio universal HiFi workflow – from extraction to data analysis. Combined with easy, intuitive run setup, the Vega system delivers reliable and consistent results.
HiFi sequencing delivers 99.9% read accuracy, enabling you to achieve long read lengths without sacrificing accuracy to address complex biological questions.
With over 1,000 peer-reviewed publications in 2023 alone and more than 1,200 PacBio sequencers globally, Vega now joins the trusted HiFi portfolio, providing data equivalent to the Revio system for consistent, high-quality results.
One Vega SMRT Cell means…
3 full-length RNA transcriptomes
48 PureTarget repeat expansion panels
384 microbial genomes
And more…
SMALL AND MIGHTY
• Innovative Revio technology shrunk to fit on a benchtop – equivalent HiFi data in a reduced instrument footprint.
• Seamless integration with HiFi library prep workflows and SMRT Link run management software.
• On-instrument primary analysis, including DeepConsensus, methylation calling, and optional barcode demultiplexing in every run.
The Vega SMRT Cell is the heart of HiFi sequencing and is powered by a semiconductor device to deliver single-molecule insights in real time.
The Vega sequencing plate holds everything you need – sample and reagents – ready to power your next game-changing insight.
A push-button run setup links the Vega sequencing plate to SMRT Link run design. Intuitive design and tactile confirmations reduce errors and steps to get to results.
No fuss, just functionality with standard power and networking for a true plug-and-play experience.
A single SMRT Cell per run means no waiting, putting you in control of your data, timelines, and budget. By sequencing in-house, you can streamline your workflows, finish projects faster, and tailor every run to your application needs—all with an instrument designed to fit your lab and your experiments.
Continuous productivity: Vega lets you pre-stage consumables for the next run—keeping you one step ahead and boosting efficiency.
Web-based SMRT Link software supports sequencing prep, run design, and data analysis in a single interface across a wide range of applications.
Vega transfers sequencing data to your preferred network or directly to Amazon, Google, or Microsoft cloud.
SMRT Analysis provides fast, easy, and powerful computational tools and workflows to get complete views of the full genome or specific region of interest and exceptionally accurate variant calling like TRGT, and more.
The Vega system goes beyond basecalling – every run also measures DNA methylation status, calculated with a deep learning algorithm. On-instrument primary analysis includes barcode demultiplexing and conversion to the standard BAM format – so you can make meaningful insights faster. Efficient data representation encodes sequence, quality values, and methylation in about 0.5 bytes per base — 20× smaller than for other long-read technologies.
Access high accuracy for all variant types — SNVs, indels, structural variants, tandem repeat expansions, and methylation — including in challenging regions.
FULL-LENGTH ISOFORM SEQUENCING
Characterize complex alternative splicing, fusion transcripts, prediction of open reading frames, and cell-type specific isoform expression.
TARGETED SEQUENCING TO STUDY GENES
Focus the power of HiFi variant calling by enriching for regions of interest using PureTarget, hybrid capture or PCR amplification.
MICROBIAL GENOMICS
Characterize, assemble, and gain a better understanding of microbial communities and metagenomics.
The Vega benchtop system delivers up to 60 Gb of HiFi data per run, methylation calling included, using a single SMRT® Cell. The onboard compute provides accurate base calling, HiFi read generation with DeepConsensus, methylation calling, barcode demultiplexing, and BAM file generation.
HiFi reads turn questions into answers by offering accurate detection of variant types from SNPs to structural variants with high precision and recall, even in challenging regions of genomes. A subset of key applications include:
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