Medical Services

Human Platelet Antigen (HPA) Genotyping

Mismatched platelet transfusions can lead to serious adverse events including platelet transfusion refractoriness (PTR) and alloimmune thrombocytopenia. Beyond transfusion, HPA polymorphisms are closely linked to disease susceptibility, platelet pathogen interactions, platelet-malignant cell interactions, and cardiovascular disease risk.

HemoSure™ HPA genotyping delivers comprehensive coverage across all HPA-1 to HPA-35 loci. Combined with AltruType™ HLA genotyping and HemoSure™ RBC genotyping, this creates a complete genotyping ecosystem for transplant medicine, bone marrow registries, and blood banking.

 Product Strengths

• Specificity

  Leveraging targeted amplification core technology, it enables high-specificity genotyping of HPA 1–35 loci. It precisely targets the desired regions, eliminating interference from non-specific amplification.

• Accuracy & Efficiency

  Built on long-read sequencing, it efficiently uncovers more HPA polymorphisms compared to traditional methodologies—achieving breakthroughs in both the accuracy and comprehensiveness of genotyping results.

• Simplicity & Minimal Sample Requirement

  Simultaneous amplification via single-tube multiplex PCR allows for comprehensive results with extremely low sample input, significantly boosting testing efficiency.

• High Flexibility

  Supports modular combination and data reuse, flexibly adapting to the blood transfusion needs of patients undergoing bone marrow transplantation, platelet transfusion, long-term transfusion, and those with complex blood types.

Application Value

1. Safety & Resource Optimization

Homologous platelet transfusion prevents transfusion refractoriness and alloimmune thrombocytopenia, ensuring patient safety while conserving blood resources. Additionally, analyzing platelet polymorphisms aids in disease susceptibility research and management.

2. Comprehensive One-Stop Solution

Leveraging PacBio HiFi and targeted amplification, we provide simultaneous genotyping for HPA, HLA, and CD36. This all-in-one solution meets core matching needs and maximizes data utility for precision diagnosis.

3. Research Empowerment

Our HPA genotyping provides essential data for studying platelet interactions with microbes and malignant cells, as well as susceptibility to cardiovascular diseases, supporting advanced clinical research.