Medical Services

Break the Ambiguity. Resolve with Confidence.

Powered by Long-Read Sequencing

       AltruType™ Long-Read HLA Genotyping is a complete sample-to-report HLA typing solution powered by PacBio HiFi sequencing. Designed for ease of use and operational efficiency, AltruType™ delivers high-resolution results up to 8- digit with gold-standard accuracy and unambiguous allele calls, all from a single streamlined workflow.

Product Highlights

Scalable and Unified Workflow

End-to-end Solutions

Application Areas

1. Allogeneic Stem Cell Transplantation (allo-HSCT)

AltruType^TM enables optimal donor selection for related, unrelated, and cord blood donors. Our high-resolution data supports precise assessment of permissible HLA mismatches, detection of HLA locus loss, and evaluation of donor-specific antibodies to ensure the best possible donor-recipient pairing.

2. Autoimmune Disease Risk Stratification

With over 500 diseases linked to HLA variation, AltruType^TM identifies disease susceptibility markers at the single-nucleotide level. For example, it distinguishes ankylosing spondylitis-risk alleles (B*27:04/05/02/07) from non-risk variants (B*27:06/09) and identifies HLA-C*06:02 carriers who show ~90% response to ustekinumab for psoriasis versus 65% in non-carriers.

3. Pharmacogenomics & Drug Safety

Aligned with FDA and CPIC guidelines, AltruType^TM screens for high-risk HLA alleles prior to drug administration to prevent severe adverse reactions. Key applications include:

• HLA-B*15:02/HLA-A*31:01 screening before carbamazepine use to avoid Stevens-Johnson syndrome/toxic epidermal necrolysis

• HLA-B*58:01 testing before allopurinol prescription

• HLA-B*57:01 screening before abacavir initiation

4. Platelet Transfusion Safety

AltruType^TM minimizes febrile non-hemolytic transfusion reactions by matching donor-recipient HLA genotypes. This is especially critical for chronically transfused patients (e.g., thalassemia), where HLA-matched platelet transfusions significantly improve safety and tolerance.

5. Recurrent Miscarriage Evaluation

AltruType^TM assesses HLA compatibility between couples to identify causes of recurrent pregnancy loss. When parental HLA similarity is too high, insufficient maternal blocking antibodies increase rejection risk. Our testing guides personalized immunotherapy, shortening treatment timelines and improving pregnancy success rates.